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Suspected bacteria and their antibiotic susceptibility pattern guide the choice of antimicrobial agents for treatment of AOM. Common bacteria known to cause AOM in children are Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis 3. However, there is relative paucity of data on middle ear pathogens as tympanocentesis is not routinely performed in children with AOM. High dose amoxicillin exceed the Minimum Inhibitory Concentration (MIC) of S. A 4 to 6 days treatment with high dose amoxicillin and clavulanate potassium has been found effective to eradicate S. On the other side, the data show that 58% to 82% of H.

• These were mild AEs and did not require modification of drug therapy.
• There was no statistically significant difference in the baseline demographic profile and baseline AOM-SOS scores.
• Cephalosporin antibiotics may be an option in these cases if the reaction is only a rash.
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American association of paediatrics also recommends amoxicillin-clavulanate potassium as the first line drug in treatment of AOM 7. Children fulfilling the selection criteria, were randomly divided into two treatment groups. Children in Group A received amoxicillin-clavulanate potassium 30 mg/kg/day (amoxicillin base) in two divided doses for 10 days. Children Group B received cefpodoxime 10 mg/kg/day in two divided doses for 10 days. Children showing worsening clinical signs or treatment failure were withdrawn prematurely from the study.

When it is all said and done, you can expect to be set up with a different antibiotic and be on your way to feeling better. These other antibiotics could also be called upon if bacterial resistance to penicillins is a concern, a not uncommon problem due to beta-lactamase enzyme production by bacteria. In fact, amoxicillin is combined with clavulanic acid, a beta-lactamase inhibitor, to make Augmentin-resistant bacteria. The details of this antibiotic and other alternatives to amoxicillin are important to know. Acute Otitis Media (AOM) is one of the frequently diagnosed diseases in children below two years.

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• Our study shows that efficacy and safety of 10 days therapy with cefpodoxime is comparable to that of amoxicillin-clavulanate potassium in PAOM in children below two years.
• Gradual increase of antimicrobial resistance and costs of antimicrobial therapy have emphasized the need of judicious and rational use of antimicrobial drugs 1,2.
• The mean age of children was 1.8 years and 1.6 years in the Group A and B respectively.
• Over all safety profile of both the study drugs was good.

Over all safety profile of both the study drugs was good. Adding the beta-lactamase inhibitor clavulanate fends off certain bacteria that would be resistant to plain amoxicillin. The enhanced action works for many ear, sinus, and lung infections cases. The downside of having more antibiotic power is a tendency for more adverse effects like diarrhea. Looking for an alternative to amoxicillin has always been necessary at times due to drug allergy or ineffectiveness. Still, in late 2022, the need reached a fever pitch due to the shortage of antibiotics.

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Thus, it can be suggested that both cefpodoxime and amoxicillin-clavulanate potassium are effective in treatment of PAOM. Inter group analysis of the AOM-SOS scores showed that there was no statistically significant difference in the baseline, day 5 and day 10 AOM-SOS scores. So, it can be suggested that both cefpodoxime and amoxicillin-clavulanate potassium are equally effective in treatment of PAOM. Ads served on select live & linear content in No Ads plan.

Inter group comparisons showed that the decrease in most of the symptoms was significantly higher in cefaclor arm as compared to amoxicillin-clavulanate potassium arm. The study showed cefaclor is well tolerated and effective treatment option for AOM in children and it is superior to the combination of amoxicillin-clavulanate potassium in efficacy and tolerability in AOM. However, the children included in the study by Agarwal M et al., were above two years of age. The mean age of the children in cefaclor group was 5.74 years and in amoxicillin-clavulanate potassium group was 4.93 years which is higher than our study group 15. Intravenous or intra-muscular administration of ceftriaxone is recommended in treatment of PAOM if amoxicillin is used within last one month for treatment of same condition 16.